Scientific Foundation
OsseoCem builds upon more than a decade of peer-reviewed biomaterials research conducted at Vanderbilt University focused on resorbable composite systems and in situ setting technologies.
Ongoing Research Collaboration
SJC Bio maintains an ongoing research collaboration with Vanderbilt University led by Professor Scott A. Guelcher, Ph.D., a leading researcher in biomaterials and regenerative engineering.
Dr. Guelcher’s laboratory has conducted more than a decade of pioneering work onresorbable polymer–ceramic composite systems and injectable biomaterials designed for load-bearing tissue regeneration.
This collaboration supports continued formulation optimization and translational development of OsseoCem as it advances toward clinical applications in dental surgery.
Representative Peer-Reviewed Publications Supporting the Scientific Foundation of OsseoCem
01
Talley AD, Jones AA, Cochran DL, Guelcher SA, Injectable compression-resistant polymer/ceramic composite bone grafts maintain space and promote bone healing without membranes in a canine model of lateral ridge augmentation, Clinical Oral Implants Research. 2018;29(6):585–597. doi:10.1111/clr.13164
02
Boller LA, Jones AA, Cochran DL, Guelcher SA, Compression-resistant polymer/ceramic composite scaffolds augmented with rhBMP-2 promote new bone formation in a non-human primate mandibular ridge augmentation model, International Journal of Oral & Maxillofacial Implants. 2020;35(1):90–102. doi:10.11607/jomi.7862
03
Talley AD, Zienkiewicz KJ, Nyman JS, Wenke JC, Guelcher SA, Effects of rhBMP-2 dose and ceramic composition on new bone formation and space maintenance in a canine mandibular ridge saddle defect model, Tissue Engineering Part A. 2016;22(5–6):487–498.
doi:10.1089/ten.TEA.2015.0372
04
McEnery MAP, Lu S, Gupta MK, Zienkiewicz KJ, Wenke JC, Kalpakci KN, Shimko DA, Duvall CL, Guelcher SA, Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength. RSC Advances. 2016; 6:109414–109424. doi:10.1039/C6RA24642GMcEnery MAP, Lu S, Gupta MK, Zienkiewicz KJ, Wenke JC, Kalpakci KN, Shimko DA, Duvall CL, Guelcher SA, Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength. RSC Advances. 2016; 6:109414–109424. doi:10.1039/C6RA24642G
05
Lu S, McGough MAP, Shiels SM, Zienkiewicz KJ, Merkel AR, Vanderburgh JP, Nyman JS, Sterling JA, Tennent DJ, Wenke JC, Guelcher SA, Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model, Biomaterials. 2018;181:50–61. doi:10.1016/j.biomaterials.2018.07.025
06
Guelcher SA, Srinivasan A, Hafeman AE, Gallagher KM, Doctor JS, Khetan S, McBride S, Hollinger JO, Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates, Biomaterials. 2008;29(12):1762–1775. doi:10.1016/j.biomaterials.2008.01.012